|Application ||WB, E|
|Calculated MW||39082 Da|
|Antigen Region||291-320 aa|
|Other Names||Calcium uniporter regulatory subunit MCUb, mitochondrial, MCUb, Coiled-coil domain-containing protein 109B, CCDC109B, MCUB|
|Target/Specificity||This C109B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 291-320 amino acids from the C-terminal region of human C109B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||C109B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.|
|Cellular Location||Mitochondrion inner membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Kalsi, G., et al. Hum. Mol. Genet. 19(12):2497-2506(2010)
Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)
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