|Application ||IHC-P, WB, FC, E|
|Other Accession||NP_001070833.1, NP_001129586.1|
|Calculated MW||84881 Da|
|Antigen Region||706-735 aa|
|Other Names||Protein O-mannosyl-transferase 1, Dolichyl-phosphate-mannose--protein mannosyltransferase 1, POMT1|
|Target/Specificity||This POMT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 706-735 amino acids from the C-terminal region of human POMT1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||POMT1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Widely expressed. Highly expressed in testis, heart and pancreas. Detected at lower levels in kidney, skeletal muscle, brain, placenta, lung and liver|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is an O-mannosyltransferase that requires interaction with the product of the POMT2 gene for enzymatic function. The encoded protein is found in the membrane of the endoplasmic reticulum. Defects in this gene are a cause of Walker-Warburg syndrome (WWS) and limb-girdle muscular dystrophy type 2K (LGMD2K). Several transcript variants encoding different isoforms have been found for this gene.
Manya, H., et al. J. Biochem. 147(3):337-344(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Cotarelo, R.P., et al. Clin. Genet. 76(1):108-112(2009)
Mercuri, E., et al. Neurology 72(21):1802-1809(2009)
Judas, M., et al. Neuropediatrics 40(1):6-14(2009)
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