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AIPL1 Antibody (N-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP12385a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP12385a-ev20 | Ev20 size 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
AIPL1 Antibody (N-term) - Product info | |
| Application | IHC, IF, WB, FC
|
| Primary Accession | Q9NZN9 |
| Other Accession | NP_001028227.1 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 43903 Da |
AIPL1 Antibody (N-term) - Additional info | |
| Gene ID 23746 | |
| Other Names AIPL1; AIPL2; Aryl-hydrocarbon-interacting protein-like 1 | |
| Target/Specificity This AIPL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 35-65 amino acids from the N-terminal region of human AIPL1. | |
| Dilution IHC~~1:10~50 IF~~1:10~50 WB~~1:100~500WB~~1:1000 FC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions AIPL1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
AIPL1 Antibody (N-term) - Protein Information | |
| Name AIPL1 | |
| Synonyms AIPL2 | |
| Function May be important in protein trafficking and/or protein folding and stabilization | |
| Cellular Location Cytoplasm. Nucleus. | |
| Tissue Location Highly expressed in retina. Specifically localized to the developing photoreceptor layer and within the photoreceptors of the adult retina | |
AIPL1 Antibody (N-term) - Related products
AP12385a: AIPL1 Antibody (N-term)
RI10192: AIPL1 predesign siRNA
AIPL1 Antibody (N-term) - Application data
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AIPL1 Antibody (N-term) (Cat. #AP12385a)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of AIPL1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Confocal immunofluorescent analysis of AIPL1 Antibody (N-term) (Cat#AP12385a) with 293 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
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AIPL1 Antibody (N-term) (Cat. #AP12385a) western blot analysis in HL-60,K562,MDA-MB453,HepG2 cell line lysates (35ug/lane).This demonstrates the AIPL1 antibody detected the AIPL1 protein (arrow).
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AIPL1) Antibody (N-term (Cat. #AP12385a) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.
AIPL1 Antibody (N-term) - Research Areas
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BACKGROUND
Leber congenital amaurosis (LCA) accounts for at least 5% of all inherited retinal disease and is the most severe inherited retinopathy with the earliest age of onset. Individuals affected with LCA are diagnosed at birth or in the first few months of life with severely impaired vision or blindness, nystagmus and an abnormal or flat electroretinogram. The photoreceptor/pineal -expressed gene, AIPL1, encoding aryl-hydrocarbon interacting protein-like 1, was mapped within the LCA4 candidate region. The protein contains three tetratricopeptide motifs, consistent with nuclear transport or chaperone activity. AIPL1 mutations may cause approximately 20% of recessive LCA.
REFERENCES
Pasadhika, S., et al. Invest. Ophthalmol. Vis. Sci. 51(5):2608-2614(2010) Kirschman, L.T., et al. Hum. Mol. Genet. 19(6):1076-1087(2010) Sundaresan, P., et al. Mol. Vis. 15, 1781-1787 (2009) : Hidalgo-de-Quintana, J., et al. Invest. Ophthalmol. Vis. Sci. 49(7):2878-2887(2008) Booij, J.C., et al. J. Med. Genet. 42 (11), E67 (2005) :
