|Application ||WB, FC, E|
|Other Accession||NP_001093109.1, NP_001093108.1, NP_009076.2|
|Calculated MW||33308 Da|
|Antigen Region||17-45 aa|
|Other Names||Zinc finger protein OZF, Only zinc finger protein, Zinc finger protein 146, ZNF146, OZF|
|Target/Specificity||This ZNF146 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-45 amino acids from the N-terminal region of human ZNF146.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ZNF146 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Liver, skeletal and heart muscle, mammary cells. Very low levels in brain, lung, placenta and kidney Strongly overexpressed in many pancreas and colorectal cancers Increased gene copy numbers are detected in 3 of 12 tumor cell lines and 2 of 12 primary pancreatic carcinomas. Overexpressed in 80% of colorectal cancers.|
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The ZNF146 protein is a 33 kDa Kruppel protein, composed solely of 10 zinc finger motifs. ZNF146 overexpression in tumours may alter the balance between hRap1 and other telomeric proteins; therefore ZNF146 function may be linked to telomere regulation. ZNF146 is strongly overexpressed in many pancreas and colorectal cancers. Increased gene copy numbers are detected in 3 of 12 tumor cell lines and 2 of 12 primary pancreatic carcinomas. ZNF146 is overexpresseed in 80% of colorectal cancers.
Antoine, K., et al. J. Cell. Biochem. 95(4):763-768(2005)
Antoine, K., et al. Mol. Cell. Biochem. 271 (1-2), 215-223 (2005) :
Grimwood, J., et al. Nature 428(6982):529-535(2004)
Ferbus, D., et al. J. Pathol. 200(2):177-182(2003)
Pibouin, L., et al. Cytogenet. Cell Genet. 92 (1-2), 80-84 (2001) :
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