SLC12A7 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
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Primary Accession | Q9Y666 |
Other Accession | NP_006589.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 119106 Da |
Antigen Region | 89-117 aa |
Gene ID | 10723 |
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Other Names | Solute carrier family 12 member 7, Electroneutral potassium-chloride cotransporter 4, K-Cl cotransporter 4, SLC12A7, KCC4 |
Target/Specificity | This SLC12A7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-117 amino acids from the N-terminal region of human SLC12A7. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SLC12A7 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SLC12A7 (HGNC:10915) |
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Function | Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:10913127). May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity). |
Cellular Location | Cell membrane; Multi-pass membrane protein |
Tissue Location | Detected in muscle, brain, lung, heart and kidney. |
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Background
SLC12A7 mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity).
References
Hartmann, A.M., et al. J. Biol. Chem. 285(31):23994-24002(2010)
Kamatani, Y., et al. Nat. Genet. 42(3):210-215(2010)
Chen, Y.F., et al. Cancer Res. 69(22):8585-8593(2009)
Fujii, T., et al. J. Biol. Chem. 284(1):619-629(2009)
Ji, W., et al. Nat. Genet. 40(5):592-599(2008)
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