|Application ||WB, IHC-P, E|
|Calculated MW||119106 Da|
|Antigen Region||89-117 aa|
|Other Names||Solute carrier family 12 member 7, Electroneutral potassium-chloride cotransporter 4, K-Cl cotransporter 4, SLC12A7, KCC4|
|Target/Specificity||This SLC12A7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-117 amino acids from the N-terminal region of human SLC12A7.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SLC12A7 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Detected in muscle, brain, lung, heart and kidney|
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Provided below are standard protocols that you may find useful for product applications.
SLC12A7 mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity).
Hartmann, A.M., et al. J. Biol. Chem. 285(31):23994-24002(2010)
Kamatani, Y., et al. Nat. Genet. 42(3):210-215(2010)
Chen, Y.F., et al. Cancer Res. 69(22):8585-8593(2009)
Fujii, T., et al. J. Biol. Chem. 284(1):619-629(2009)
Ji, W., et al. Nat. Genet. 40(5):592-599(2008)
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