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SLC12A7 Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - SLC12A7 Antibody (N-term) AP12392a
    SLC12A7 Antibody (N-term) (Cat. #AP12392a) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the SLC12A7 antibody detected the SLC12A7 protein (arrow).
    detail
  • IHC-P - SLC12A7 Antibody (N-term) AP12392a
    SLC12A7 Antibody (N-term) (Cat. #AP12392a)immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SLC12A7 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, WB, E
Primary Accession Q9Y666
Other Accession NP_006589.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 119106 Da
Antigen Region 89-117 aa
Additional Information
Gene ID 10723
Other Names Solute carrier family 12 member 7, Electroneutral potassium-chloride cotransporter 4, K-Cl cotransporter 4, SLC12A7, KCC4
Target/Specificity This SLC12A7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-117 amino acids from the N-terminal region of human SLC12A7.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSLC12A7 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC12A7 (HGNC:10915)
Function Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:10913127). May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Detected in muscle, brain, lung, heart and kidney.
Research Areas
Citations (0)
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Background

SLC12A7 mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity).

References

Hartmann, A.M., et al. J. Biol. Chem. 285(31):23994-24002(2010)
Kamatani, Y., et al. Nat. Genet. 42(3):210-215(2010)
Chen, Y.F., et al. Cancer Res. 69(22):8585-8593(2009)
Fujii, T., et al. J. Biol. Chem. 284(1):619-629(2009)
Ji, W., et al. Nat. Genet. 40(5):592-599(2008)

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$ 365.00
$ 140.00
Cat# AP12392a
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