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SLC16A3 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P-Leica, WB, E |
|---|---|
| Primary Accession | O15427 |
| Other Accession | O35910, P57787, NP_001035887.1, NP_001035888.1 |
| Reactivity | Human, Mouse, Rat |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 49469 Da |
| Antigen Region | 433-462 aa |
| Gene ID | 9123 |
|---|---|
| Other Names | Monocarboxylate transporter 4, MCT 4, Solute carrier family 16 member 3, SLC16A3, MCT4 |
| Target/Specificity | This SLC16A3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 433-462 amino acids from the C-terminal region of human SLC16A3. |
| Dilution | WB~~1:1000 IHC-P-Leica~~1:500 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SLC16A3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC16A3 |
|---|---|
| Synonyms | MCT3 {ECO:0000303|PubMed:9425115}, MCT4 |
| Function | Proton-dependent transporter of monocarboxylates such as L- lactate and pyruvate (PubMed:11101640, PubMed:23935841, PubMed:31719150). Plays a predominant role in L-lactate efflux from highly glycolytic cells (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Note=Plasma membrane localization is dependent upon the BSG/MCT4 interaction (PubMed:10921872). Basolateral sorting signals (BLSS) in C-terminal cytoplasmic tail ensure its basolateral expression in polarised epithelial cells (PubMed:21199217) |
| Tissue Location | Highly expressed in skeletal muscle. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 [PubMed 9425115]).
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Vellonen, K.S., et al. Eur J Pharm Sci 39(4):241-247(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Wang, Q., et al. Drug Metab. Dispos. 35(8):1393-1399(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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