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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   NKAP Antibody (C-term)   

NKAP Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - NKAP Antibody (C-term) AP12401b
    NKAP Antibody (C-term) (Cat. #AP12401b) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the NKAP antibody detected the NKAP protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8N5F7
Other Accession Q4V7C9, Q9D0F4, NP_078804.2
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 47138 Da
Antigen Region 387-415 aa
Additional Information
Gene ID 79576
Other Names NF-kappa-B-activating protein, NKAP
Target/Specificity This NKAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 387-415 amino acids from the C-terminal region of human NKAP.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNKAP Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter.
Cellular Location Nucleus.
Research Areas
Citations (0)

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This gene encodes a protein that is involved in the activation of the ubiquitous transcription factor NF-kappaB. This protein is associated with the the histone deacetylase HDAC3 and with the Notch corepressor complex, and it thereby acts as a transcriptional repressor of Notch target genes. It is also required for alphabeta T cell development. A related pseudogene has been identified on chromosome X, while a related and intronless retrocopy, which has an intact CDS and may be functional, is located on chromosome 6.


D'Addabbo, A., et al. Artif Intell Med 46(2):131-138(2009)
Pajerowski, A.G., et al. Immunity 30(5):696-707(2009)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Chen, D., et al. Biochem. Biophys. Res. Commun. 310(3):720-724(2003)

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Cat# AP12401b
(40 western blots)
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