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NKAP Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8N5F7 |
| Other Accession | Q4V7C9, Q9D0F4, NP_078804.2, Q5SZT7 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 47138 Da |
| Antigen Region | 387-415 aa |
| Gene ID | 79576 |
|---|---|
| Other Names | NF-kappa-B-activating protein, NKAP |
| Target/Specificity | This NKAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 387-415 amino acids from the C-terminal region of human NKAP. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NKAP Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NKAP |
|---|---|
| Function | Acts as a transcriptional repressor (PubMed:14550261, PubMed:19409814, PubMed:31587868). Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development (PubMed:19409814). Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch- regulated SKP2 promoter. |
| Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein that is involved in the activation of the ubiquitous transcription factor NF-kappaB. This protein is associated with the the histone deacetylase HDAC3 and with the Notch corepressor complex, and it thereby acts as a transcriptional repressor of Notch target genes. It is also required for alphabeta T cell development. A related pseudogene has been identified on chromosome X, while a related and intronless retrocopy, which has an intact CDS and may be functional, is located on chromosome 6.
References
D'Addabbo, A., et al. Artif Intell Med 46(2):131-138(2009)
Pajerowski, A.G., et al. Immunity 30(5):696-707(2009)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Chen, D., et al. Biochem. Biophys. Res. Commun. 310(3):720-724(2003)
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