|Application ||WB, E|
|Other Accession||Q4V7C9, Q9D0F4, NP_078804.2, Q5SZT7|
|Calculated MW||47138 Da|
|Antigen Region||387-415 aa|
|Other Names||NF-kappa-B-activating protein, NKAP|
|Target/Specificity||This NKAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 387-415 amino acids from the C-terminal region of human NKAP.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NKAP Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that is involved in the activation of the ubiquitous transcription factor NF-kappaB. This protein is associated with the the histone deacetylase HDAC3 and with the Notch corepressor complex, and it thereby acts as a transcriptional repressor of Notch target genes. It is also required for alphabeta T cell development. A related pseudogene has been identified on chromosome X, while a related and intronless retrocopy, which has an intact CDS and may be functional, is located on chromosome 6.
D'Addabbo, A., et al. Artif Intell Med 46(2):131-138(2009)
Pajerowski, A.G., et al. Immunity 30(5):696-707(2009)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Chen, D., et al. Biochem. Biophys. Res. Commun. 310(3):720-724(2003)
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