|Application ||WB, E|
|Calculated MW||31457 Da|
|Antigen Region||275-300 aa|
|Other Names||Free fatty acid receptor 1, G-protein coupled receptor 40, FFAR1, GPR40|
|Target/Specificity||This FFAR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 275-300 amino acids from the C-terminal region of human FFAR1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FFAR1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose- stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Detected in brain and pancreas. Detected in pancreatic beta cells.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved in the metabolic regulation of insulin secretion. Polymorphisms in this gene may be associated with type 2 diabetes.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Lu, S.Y., et al. J. Mol. Graph. Model. 28(8):766-774(2010)
Del Guerra, S., et al. Nutr Metab Cardiovasc Dis 20(1):22-25(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Nagasumi, K., et al. Diabetes 58(5):1067-1076(2009)
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