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FFAR1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - FFAR1 Antibody (C-term) AP12402B
    FFAR1 Antibody (C-term) (Cat. #AP12402b) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the FFAR1 antibody detected the FFAR1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O14842
Other Accession NP_005294.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 31457 Da
Antigen Region 275-300 aa
Additional Information
Gene ID 2864
Other Names Free fatty acid receptor 1, G-protein coupled receptor 40, FFAR1, GPR40
Target/Specificity This FFAR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 275-300 amino acids from the C-terminal region of human FFAR1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFFAR1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FFAR1
Synonyms GPR40
Function G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose- stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway.
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Detected in brain and pancreas. Detected in pancreatic beta cells.
Research Areas
Citations (0)

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This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved in the metabolic regulation of insulin secretion. Polymorphisms in this gene may be associated with type 2 diabetes.


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Lu, S.Y., et al. J. Mol. Graph. Model. 28(8):766-774(2010)
Del Guerra, S., et al. Nutr Metab Cardiovasc Dis 20(1):22-25(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Nagasumi, K., et al. Diabetes 58(5):1067-1076(2009)

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Cat# AP12402B
(40 western blots)
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