|Application ||WB, E|
|Calculated MW||35464 Da|
|Other Names||Docking protein 5, Downstream of tyrosine kinase 5, Insulin receptor substrate 6, IRS-6, IRS6, DOK5, C20orf180|
|Target/Specificity||This Dok5 antibody is generated from rabbits immunized with a recombinant protein (GST-tag removed) from human Dok5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Dok5 Antibody (PTB domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.|
|Tissue Location||Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes.|
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Provided below are standard protocols that you may find useful for product applications.
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.
Liu, X., et al. J Am Acad Child Adolesc Psychiatry 49(1):33-41(2010)
Tabassum, R., et al. BMC Med. Genet. 11, 35 (2010) :
Shi, L., et al. Cell. Signal. 18(11):1995-2003(2006)
Cai, D., et al. J. Biol. Chem. 278(28):25323-25330(2003)
Favre, C., et al. Genes Immun. 4(1):40-45(2003)
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