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Dok5 Antibody (PTB domain)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Dok5 Antibody (PTB domain) AP12411a
    Western blot analysis of Dok5 (arrow) using rabbit polyclonal Dok5 Antibody (PTB domain) (Cat. #AP12411a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the Dok5 gene.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9P104
Other Accession NP_060901.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 35464 Da
Additional Information
Gene ID 55816
Other Names Docking protein 5, Downstream of tyrosine kinase 5, Insulin receptor substrate 6, IRS-6, IRS6, DOK5, C20orf180
Target/Specificity This Dok5 antibody is generated from rabbits immunized with a recombinant protein (GST-tag removed) from human Dok5.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDok5 Antibody (PTB domain) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DOK5
Synonyms C20orf180
Function DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.
Tissue Location Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes.
Research Areas
Citations (0)

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Background

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.

References

Liu, X., et al. J Am Acad Child Adolesc Psychiatry 49(1):33-41(2010)
Tabassum, R., et al. BMC Med. Genet. 11, 35 (2010) :
Shi, L., et al. Cell. Signal. 18(11):1995-2003(2006)
Cai, D., et al. J. Biol. Chem. 278(28):25323-25330(2003)
Favre, C., et al. Genes Immun. 4(1):40-45(2003)

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Cat# AP12411a
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(40 western blots)
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