|Application ||WB, IHC-P, E|
|Other Accession||NP_004359.1, NP_958434.1|
|Calculated MW||33697 Da|
|Antigen Region||9-36 aa|
|Other Names||Calponin-2, Calponin H2, smooth muscle, Neutral calponin, CNN2|
|Target/Specificity||This CNN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-36 amino acids from the N-terminal region of human CNN2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CNN2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.|
|Tissue Location||Heart and smooth muscle.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene, which can bind actin, calmodulin, troponin C, and tropomyosin, may function in the structural organization of actin filaments. The encoded protein could play a role in smooth muscle contraction and cell adhesion. Two transcript variants encoding different isoforms have been found for this gene.
Rikova, K., et al. Cell 131(6):1190-1203(2007)
Hossain, M.M., et al. J. Biol. Chem. 280(51):42442-42453(2005)
Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)
Gevaert, K., et al. Nat. Biotechnol. 21(5):566-569(2003)
Hossain, M.M., et al. Am. J. Physiol., Cell Physiol. 284 (1), C156-C167 (2003) :
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