FBXO15 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | Q8NCQ5 |
Other Accession | Q9GKV7, NP_689889.1 |
Reactivity | Human |
Predicted | Monkey |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 57258 Da |
Antigen Region | 130-158 aa |
Gene ID | 201456 |
---|---|
Other Names | F-box only protein 15, FBXO15, FBX15 |
Target/Specificity | This FBXO15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 130-158 amino acids from the N-terminal region of human FBXO15. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | FBXO15 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | FBXO15 |
---|---|
Synonyms | FBX15 |
Function | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Members of the F-box protein family, such as FBXO15, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM].
References
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Jin, J., et al. Genes Dev. 18(21):2573-2580(2004)
Tokuzawa, Y., et al. Mol. Cell. Biol. 23(8):2699-2708(2003)
Winston, J.T., et al. Curr. Biol. 9(20):1180-1182(1999)
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