SPATA7 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9P0W8 |
Other Accession | NP_060888.2, NP_001035518.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 67719 Da |
Antigen Region | 374-401 aa |
Gene ID | 55812 |
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Other Names | Spermatogenesis-associated protein 7, HSD-31, Spermatogenesis-associated protein HSD3, SPATA7, HSD3 |
Target/Specificity | This SPATA7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 374-401 amino acids from the C-terminal region of human SPATA7. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SPATA7 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SPATA7 |
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Synonyms | HSD3 |
Function | Involved in the maintenance of both rod and cone photoreceptor cells (By similarity). It is required for recruitment and proper localization of RPGRIP1 to the photoreceptor connecting cilium (CC), as well as photoreceptor-specific localization of proximal CC proteins at the distal CC (By similarity). Maintenance of protein localization at the photoreceptor-specific distal CC is essential for normal microtubule stability and to prevent photoreceptor degeneration (By similarity). |
Cellular Location | Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q80VP2}. Note=Localizes to the microtubule network. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene, originally isolated from testis, is also expressed in retina. Mutations in this gene are associated with Leber congenital amaurosis and juvenile retinitis pigmentosa. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
References
Perrault, I., et al. Hum. Mutat. 31 (3), E1241-E1250 (2010) :
Wang, H., et al. Am. J. Hum. Genet. 84(3):380-387(2009)
Zhang, X., et al. J. Mol. Med. 81(6):380-387(2003)
Heilig, R., et al. Nature 421(6923):601-607(2003)
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