|Application ||WB, E|
|Calculated MW||119658 Da|
|Antigen Region||709-740 aa|
|Other Names||Sentrin-specific protease 7, SUMO-1-specific protease 2, Sentrin/SUMO-specific protease SENP7, SENP7, KIAA1707, SSP2, SUSP2|
|Target/Specificity||This SENP7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 709-740 amino acids from the C-terminal region of human SENP7.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SENP7 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA1707, SSP2, SUSP2|
|Function||Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full- length SUMO proteins to their mature forms.|
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Provided below are standard protocols that you may find useful for product applications.
SENP7 is a protease that may be involved in two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature conjugatable forms and/or deconjugation of SUMO1, SUMO2 and SUMO3 from targeted substrate proteins.
Wiemann, S., et al., Genome Res. 11(3):422-435 (2001).
Nagase, T., et al., DNA Res. 7(6):347-355 (2000).
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