|Application ||WB, E|
|Calculated MW||28619 Da|
|Antigen Region||44-72 aa|
|Other Names||RBPJ-interacting and tubulin-associated protein 1, RBPJ-interacting and tubulin-associated protein, RITA1, C12orf52, RITA|
|Target/Specificity||This CL052 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 44-72 amino acids from the N-terminal region of human CL052.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CL052 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.|
|Cellular Location||Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Shuttles rapidly between the cytoplasm and the nucleus. The function of centrosome localization is still unclear|
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Lamesch, P., et al. Genomics 89(3):307-315(2007)
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