|Application ||WB, E|
|Calculated MW||88755 Da|
|Antigen Region||674-703 aa|
|Other Names||Transferrin receptor protein 2, TfR2, TFR2|
|Target/Specificity||This TFR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 674-703 amino acids from the C-terminal region of human TFR2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TFR2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation.|
|Cellular Location||Cell membrane; Single-pass type II membrane protein|
|Tissue Location||Predominantly expressed in liver. While the alpha form is also expressed in spleen, lung, muscle, prostate and peripheral blood mononuclear cells, the beta form is expressed in all tissues tested, albeit weakly|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the transferrin receptor-like family and encodes a single-pass type II membrane protein with a protease associated (PA) domain, an M28 peptidase domain and a transferrin receptor-like dimerization domain. This protein mediates cellular uptake of transferrin-bound iron and mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)
Ikuta, K., et al. J. Mol. Biol. 397(2):375-384(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Volke, M., et al. PLoS ONE 4 (11), E7875 (2009) :
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