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SEPN1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • IHC-P - SEPN1 Antibody (C-term) AP12452B
    SEPN1 Antibody (C-term) (Cat. #AP12452b)immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SEPN1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • WB - SEPN1 Antibody (C-term) AP12452B
    SEPN1 Antibody (C-term) (Cat. #AP12452b) western blot analysis in Hela,HepG2 cell line lysates (35ug/lane).This demonstrates the SEPN1 antibody detected the SEPN1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NZV5
Other Accession NP_996809.1, NP_065184.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 65813 Da
Antigen Region 417-445 aa
Additional Information
Gene ID 57190
Other Names Selenoprotein N, SelN, SEPN1, SELN
Target/Specificity This SEPN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 417-445 amino acids from the C-terminal region of human SEPN1.
Dilution IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSEPN1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SEPN1
Synonyms SELN
Cellular Location Isoform 2: Endoplasmic reticulum membrane. Note=Probably membrane-associated
Tissue Location Isoform 1 and isoform 2 are expressed in skeletal muscle, brain, lung and placenta. Isoform 2 is also expressed in heart, diaphragm and stomach
Citations (0)

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This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Mutations in this gene cause the classical phenotype of multiminicore disease and congenital muscular dystrophy with spinal rigidity and restrictive respiratory syndrome. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.


Arbogast, S., et al. Ann. Neurol. 65(6):677-686(2009)
Maiti, B., et al. Hum. Mutat. 30(3):411-416(2009)
Jurynec, M.J., et al. Proc. Natl. Acad. Sci. U.S.A. 105(34):12485-12490(2008)
Lin, L., et al. PLoS Genet. 4 (10), E1000225 (2008) :
Wu, C., et al. Proteomics 7(11):1775-1785(2007)

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Cat# AP12452B
(40 western blots)
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