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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   HIPK1 Antibody (C-term)   

HIPK1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - HIPK1 Antibody (C-term) AP12465b
    Western blot analysis of HIPK1 Antibody (C-term) Pab (Cat. #AP12465b) pre-incubated without(lane 1) and with(lane 2) blocking peptide in MCF-7 cell line lysate. HIPK1 Antibody (C-term) (arrow) was detected using the purified Pab.
  • IHC-P - HIPK1 Antibody (C-term) AP12465b
    HIPK1 Antibody (C-term) (Cat. #AP12465b)immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of HIPK1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q86Z02
Other Accession O88904, NP_938009.1, NP_938010.1
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 130843 Da
Antigen Region 893-922 aa
Additional Information
Gene ID 204851
Other Names Homeodomain-interacting protein kinase 1, Nuclear body-associated kinase 2, HIPK1, KIAA0630, MYAK, NBAK2
Target/Specificity This HIPK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 893-922 amino acids from the C-terminal region of human HIPK1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHIPK1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HIPK1
Synonyms KIAA0630, MYAK, NBAK2
Function Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti- oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation.
Cellular Location Nucleus. Cytoplasm. Note=Predominantly nuclear. Translocates from nucleus to cytoplasm in response to stress stimuli via SENP1-mediated desumoylation
Tissue Location Ubiquitously expressed with highest levels in skeletal muscle and heart. Overexpressed in breast cancer cell lines. Isoform 2 is highly expressed in testis
Research Areas
Citations (0)

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The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms.


Matre, V., et al. Biochem. Biophys. Res. Commun. 388(1):150-154(2009)
Li, X., et al. J. Biol. Chem. 280(15):15061-15070(2005)
Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)
Colland, F., et al. Genome Res. 14(7):1324-1332(2004)
Song, J.J., et al. J. Biol. Chem. 278(47):47245-47252(2003)

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$ 295.00
$ 99.00
Cat# AP12465b
(40 western blots)
Availability: In Stock
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