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SPG7 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SPG7 Antibody (Center) AP12476c
    SPG7 Antibody (Center) (Cat. #AP12476c) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the SPG7 antibody detected the SPG7 protein (arrow).
  • IHC-P - SPG7 Antibody (Center) AP12476c
    SPG7 Antibody (Center) (Cat. #AP12476c)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SPG7 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UQ90
Other Accession NP_955399.1, NP_003110.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 88235 Da
Antigen Region 115-141 aa
Additional Information
Gene ID 6687
Other Names Paraplegin, 3424-, Spastic paraplegia 7 protein, SPG7, CAR, CMAR, PGN
Target/Specificity This SPG7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-141 amino acids from the Central region of human SPG7.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSPG7 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SPG7
Synonyms CAR, CMAR, PGN
Function Putative ATP-dependent zinc metalloprotease.
Cellular Location Mitochondrion membrane; Multi-pass membrane protein
Tissue Location Ubiquitous.
Research Areas
Citations (0)

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This gene encodes a nuclear-encoded mitochondrial metalloprotease protein that is a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. Two transcript variants encoding distinct isoforms have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 7. [provided by RefSeq].


Warnecke, T., et al. Mov. Disord. 25(4):413-420(2010)
Augustin, S., et al. Mol. Cell 35(5):574-585(2009)
Karlberg, T., et al. PLoS ONE 4 (10), E6975 (2009) :
Brugman, F., et al. Neurology 71(19):1500-1505(2008)
Tzoulis, C., et al. J. Neurol. 255(8):1142-1144(2008)

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Cat# AP12476c
(40 western blots)
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