|Application ||WB, IHC-P, E|
|Other Accession||Q6GM16, P97346, NP_071908.2|
|Calculated MW||48392 Da|
|Antigen Region||221-249 aa|
|Other Names||Nucleoredoxin, NXN, NRX|
|Target/Specificity||This NXN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 221-249 amino acids from the Central region of human NXN.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NXN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A) (By similarity).|
|Cellular Location||Cytoplasm, cytosol. Nucleus|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
NXN functions as a redox-dependent negative regulator of the Wnt signaling pathway. May function as a transcriptional regulator. May regulate phosphatase 2A (By similarity).
Ollila, H.M., et al. Mol. Psychiatry 14(4):351-353(2009)
Funato, Y., et al. Antioxid. Redox Signal. 9(8):1035-1057(2007)
Hirota, K., et al. Biochem. Biophys. Res. Commun. 274(1):177-182(2000)
Kurooka, H., et al. Genomics 39(3):331-339(1997)
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