|Application ||WB, E|
|Other Accession||O93366, NP_005512.1|
|Calculated MW||34365 Da|
|Antigen Region||163-191 aa|
|Other Names||T-cell leukemia homeobox protein 1, Homeobox protein Hox-11, Proto-oncogene TCL-3, T-cell leukemia/lymphoma protein 3, TLX1, HOX11, TCL3|
|Target/Specificity||This TLX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 163-191 amino acids from the Central region of human TLX1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TLX1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants.
De Keersmaecker, K., et al. Nat. Med. 16(11):1321-1327(2010)
Milech, N., et al. Leuk. Res. 34(3):358-363(2010)
Zweier-Renn, L.A., et al. Genes Chromosomes Cancer 49(2):119-131(2010)
Riz, I., et al. Mol. Cancer 9, 181 (2010) :
Dear, T.N., et al. Proc. Natl. Acad. Sci. U.S.A. 90(10):4431-4435(1993)
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