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TLX1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P31314 |
| Other Accession | O93366, NP_005512.1 |
| Reactivity | Mouse |
| Predicted | Chicken |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 34365 Da |
| Antigen Region | 163-191 aa |
| Gene ID | 3195 |
|---|---|
| Other Names | T-cell leukemia homeobox protein 1, Homeobox protein Hox-11, Proto-oncogene TCL-3, T-cell leukemia/lymphoma protein 3, TLX1, HOX11, TCL3 |
| Target/Specificity | This TLX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 163-191 amino acids from the Central region of human TLX1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TLX1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TLX1 |
|---|---|
| Synonyms | HOX11, TCL3 |
| Function | Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'. |
| Cellular Location | Nucleus. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants.
References
De Keersmaecker, K., et al. Nat. Med. 16(11):1321-1327(2010)
Milech, N., et al. Leuk. Res. 34(3):358-363(2010)
Zweier-Renn, L.A., et al. Genes Chromosomes Cancer 49(2):119-131(2010)
Riz, I., et al. Mol. Cancer 9, 181 (2010) :
Dear, T.N., et al. Proc. Natl. Acad. Sci. U.S.A. 90(10):4431-4435(1993)
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