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DNAJB6 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - DNAJB6 Antibody (Center) AP12493c
    Western blot analysis of DNAJB6 Antibody (Center) Pab (Cat. #AP12493c) pre-incubated without(lane 1) and with(lane 2) blocking peptide in Hela cell line lysate. DNAJB6 Antibody (Center) (arrow) was detected using the purified Pab.
  • IHC-P - DNAJB6 Antibody (Center) AP12493c
    DNAJB6 Antibody (Center) (Cat. #AP12493c)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of DNAJB6 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - DNAJB6 Antibody (Center) AP12493c
    DNAJB6 Antibody (Center) (Cat. #AP12493c) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O75190
Other Accession NP_490647.1, NP_005485.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 36087 Da
Antigen Region 218-247 aa
Additional Information
Gene ID 10049
Other Names DnaJ homolog subfamily B member 6, HHDJ1, Heat shock protein J2, HSJ-2, MRJ, MSJ-1, DNAJB6, HSJ2, MRJ, MSJ1
Target/Specificity This DNAJB6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-247 amino acids from the Central region of human DNAJB6.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDNAJB6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms HSJ2, MRJ, MSJ1
Function Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity.
Cellular Location Cytoplasm, perinuclear region. Nucleus. Cytoplasm, myofibril, sarcomere, Z line
Tissue Location Widely expressed. Highest levels in testis and brain, and lower levels in heart, spleen, intestine, ovary, placenta, lung, kidney, pancreas, thymus, prostate, skeletal muscle, liver and leukocytes. In testis, expressed in germ cells in the earlier stages of differentiation pathway as well as in spermatids. In brain, expressed at a higher level in hippocampus and thalamus and a lower level in amygdala, substantia nigra, corpus callosum and caudate nucleus.
Research Areas
Citations (0)

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This gene encodes a member of the DNAJ protein family. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. This family member may also play a role in polyglutamine aggregation in specific neurons. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described.


Mitra, A., et al. J. Biol. Chem. 285(32):24686-24694(2010)
Edo De Bock, C., et al. Int. J. Oncol. 36(5):1155-1163(2010)
Hageman, J., et al. Mol. Cell 37(3):355-369(2010)
Lowe, J.K., et al. PLoS Genet. 5 (2), E1000365 (2009) :
Dey, S., et al. Mol. Cell. Biochem. 322 (1-2), 137-142 (2009) :

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$ 295.00
$ 99.00
Cat# AP12493c
(40 western blots)
Availability: In Stock
Bulk Size
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