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ARG2 Antibody (C-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP12496b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP12496b-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
ARG2 Antibody (C-term) - Product info | |
| Application | WB, IHC, IF, FC
|
| Primary Accession | P78540 |
| Other Accession | NP_001163.1 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 38578 Da |
ARG2 Antibody (C-term) - Additional info | |
| Gene ID 384 | |
| Other Names ARG2; Arginase-2, mitochondrial; Kidney-type arginase; Non-hepatic arginase; Type II arginase | |
| Target/Specificity This ARG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 324-354 amino acids from the C-terminal region of human ARG2. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:10~50 IF~~1:10~50 FC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ARG2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
ARG2 Antibody (C-term) - Protein Information | |
| Name ARG2 | |
| Function May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders | |
| Cellular Location Mitochondrion. | |
| Tissue Location Expressed most strongly in kidney and prostate, much less strongly in the brain, skeletal muscle, placenta, lung, mammary gland, macrophage, uterus, testis and gut, but apparently not in the liver, heart and pancreas | |
ARG2 Antibody (C-term) - Related products
AP12496b: ARG2 Antibody (C-term)
ARG2 Antibody (C-term) - Application data
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ARG2 Antibody (C-term) (Cat. #AP12496b) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the ARG2 antibody detected the ARG2 protein (arrow).
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ARG2 Antibody (C-term) (Cat. #AP12496b)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ARG2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Confocal immunofluorescent analysis of ARG2 Antibody (C-term) (Cat#AP12496b) with 293 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
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ARG2 Antibody (C-term) (Cat. #AP12496b) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.
ARG2 Antibody (C-term) - Research Areas
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BACKGROUND
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described.
REFERENCES
Warnken, M., et al. Naunyn Schmiedebergs Arch. Pharmacol. 381(4):297-304(2010) Rodrigues Pereira, N., et al. Blood Cells Mol. Dis. 44(3):164-168(2010) Vonk, J.M., et al. Pharmacogenet. Genomics 20(3):179-186(2010) Bjelakovic, L., et al. J Basic Clin Physiol Pharmacol 21(2):187-200(2010) Gannon, P.O., et al. PLoS ONE 5 (8), E12107 (2010) :
