|Application ||WB, E|
|Calculated MW||64424 Da|
|Antigen Region||357-385 aa|
|Other Names||Protein FAM83D, Spindle protein CHICA, FAM83D, C20orf129|
|Target/Specificity||This FA83D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 357-385 amino acids from the C-terminal region of human FA83D.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FA83D Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for proper chromosome congression and alignment during mitosis. Required for targeting KIF22/KID to the spindle microtubules.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Primarily cytoplasmic during interphase, but beginning in prophase, associates with spindle microtubules, with a clear concentration toward the spindle poles. It persists on spindle microtubules through metaphase and anaphase|
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Provided below are standard protocols that you may find useful for product applications.
FA83D is required for proper chromosome congression and alignment during mitosis. Required for targeting KIF22/KID to the spindle microtubules.
Santamaria, A., et al. Curr. Biol. 18(10):723-729(2008) Nousiainen, M., et al. Proc. Natl. Acad. Sci. U.S.A. 103(14):5391-5396(2006) Deloukas, P., et al. Nature 414(6866):865-871(2001)
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