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FA83D Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9H4H8 |
| Other Accession | NP_112181.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 64424 Da |
| Antigen Region | 357-385 aa |
| Gene ID | 81610 |
|---|---|
| Other Names | Protein FAM83D, Spindle protein CHICA, FAM83D, C20orf129 |
| Target/Specificity | This FA83D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 357-385 amino acids from the C-terminal region of human FA83D. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FA83D Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FAM83D (HGNC:16122) |
|---|---|
| Function | Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC (PubMed:24344117). May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade (PubMed:25646692). May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22 (PubMed:18485706). |
| Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton, spindle Cytoplasm, cytoskeleton, spindle pole. Note=Primarily cytoplasmic during interphase, but at prophase, associates with spindle microtubules, with a clear concentration toward the spindle poles. It persists on spindle microtubules through metaphase and anaphase |
| Tissue Location | Expressed in the testis. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
FA83D is required for proper chromosome congression and alignment during mitosis. Required for targeting KIF22/KID to the spindle microtubules.
References
Santamaria, A., et al. Curr. Biol. 18(10):723-729(2008) Nousiainen, M., et al. Proc. Natl. Acad. Sci. U.S.A. 103(14):5391-5396(2006) Deloukas, P., et al. Nature 414(6866):865-871(2001)
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