|Application ||WB, IHC-P, E|
|Other Accession||O35927, NP_001323.1|
|Calculated MW||132656 Da|
|Antigen Region||1131-1159 aa|
|Other Names||Catenin delta-2, Delta-catenin, GT24, Neural plakophilin-related ARM-repeat protein, NPRAP, Neurojungin, CTNND2, NPRAP|
|Target/Specificity||This CTNND2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1131-1159 amino acids from the C-terminal region of human CTNND2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CTNND2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules.|
|Cellular Location||Nucleus. Cell junction, adherens junction. Perikaryon. Note=Colocalizes with CDK5 in the cell body of neuronal cells|
|Tissue Location||Predominantly expressed in brain; accumulates in cortical neurons (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Zhang, J., et al. Exp. Cell Res. 316(6):1070-1081(2010)
Yang, I., et al. Mol. Cells 29(3):233-237(2010)
Stenzel, N., et al. J. Cell. Sci. 122 (PT 18), 3374-3384 (2009) :
Martins-de-Souza, D., et al. Eur Arch Psychiatry Clin Neurosci 259(3):151-163(2009)
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