|Application ||WB, IHC-P, E|
|Other Accession||Q8K3J1, Q60HE3, Q22619, P42028, NP_002487.1|
|Predicted||Bovine, C.Elegans, Monkey, Mouse|
|Calculated MW||23705 Da|
|Antigen Region||81-108 aa|
|Other Names||NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial, Complex I-23kD, CI-23kD, NADH-ubiquinone oxidoreductase 23 kDa subunit, TYKY subunit, NDUFS8|
|Target/Specificity||This NDUFS8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-108 amino acids from the Central region of human NDUFS8.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NDUFS8 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). May donate electrons to ubiquinone.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a subunit of mitochondrial NADH:ubiquinone oxidoreductase, or Complex I, a multimeric enzyme of the respiratory chain responsible for NADH oxidation, ubiquinone reduction, and the ejection of protons from mitochondria. The encoded protein is involved in the binding of two of the six to eight iron-sulfur clusters of Complex I and, as such, is required in the electron transfer process. Mutations in this gene have been associated with Leigh syndrome.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) : Bourges, I., et al. Biochem. J. 383 (PT 3), 491-499 (2004) : Procaccio, V., et al. Neurology 62(10):1899-1901(2004) Ugalde, C., et al. Hum. Mol. Genet. 13(6):659-667(2004) Murray, J., et al. J. Biol. Chem. 278(39):37223-37230(2003)
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