GDF15 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, IHC-P, WB, E |
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Primary Accession | Q99988 |
Other Accession | NP_004855.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 34140 Da |
Antigen Region | 51-79 aa |
Gene ID | 9518 |
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Other Names | Growth/differentiation factor 15, GDF-15, Macrophage inhibitory cytokine 1, MIC-1, NSAID-activated gene 1 protein, NAG-1, NSAID-regulated gene 1 protein, NRG-1, Placental TGF-beta, Placental bone morphogenetic protein, Prostate differentiation factor, GDF15, MIC1, PDF, PLAB, PTGFB |
Target/Specificity | This GDF15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51-79 amino acids from the N-terminal region of human GDF15. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | GDF15 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GDF15 (HGNC:30142) |
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Function | Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:23468844, PubMed:29046435). Binds to its receptor, GFRAL, and activates GFRAL- expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions (PubMed:28953886). On hepatocytes, inhibits growth hormone signaling (By similarity). |
Cellular Location | Secreted |
Tissue Location | Highly expressed in placenta, with lower levels in prostate and colon and some expression in kidney (PubMed:9348093) Detected in plasma (at protein level) (PubMed:28572090, PubMed:29046435). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Bone morphogenetic proteins (e.g., BMP9; MIM 605120) are members of the transforming growth factor-beta (see TGFB1; MIM 190180) superfamily and regulate tissue differentiation and maintenance. They are synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein.
References
Anand, I.S., et al. Circulation 122(14):1387-1395(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Staff, A.C., et al. Gynecol. Oncol. 118(3):237-243(2010)
Roth, P., et al. Clin. Cancer Res. 16(15):3851-3859(2010)
Huh, S.J., et al. Am. J. Pathol. 176(6):2948-2957(2010)
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