|Application ||WB, IHC-P, FC, E|
|Other Accession||NP_775628.1, NP_003656.2|
|Calculated MW||32903 Da|
|Antigen Region||214-243 aa|
|Other Names||Ficolin-3, Collagen/fibrinogen domain-containing lectin 3 p35, Collagen/fibrinogen domain-containing protein 3, Hakata antigen, FCN3, FCNH, HAKA1|
|Target/Specificity||This FCN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 214-243 amino acids from the C-terminal region of human FCN3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FCN3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota.|
|Cellular Location||Secreted. Note=Found in blood plasma, bronchus, alveolus and bile duct|
|Tissue Location||Liver and lung. In liver it is produced by bile duct epithelial cells and hepatocytes. In lung it is produced by both ciliated bronchial epithelial cells and type II alveolar epithelial cells.|
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Provided below are standard protocols that you may find useful for product applications.
Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified.
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Andersen, T., et al. J. Rheumatol. 36(4):757-759(2009)
Ruskamp, J.M., et al. Clin. Exp. Immunol. 155(3):433-440(2009)
Lacroix, M., et al. J. Immunol. 182(1):456-465(2009)
Munthe-Fog, L., et al. Mol. Immunol. 45(9):2660-2666(2008)
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