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>   home   >   Products   >   Primary Antibodies   >   Metabolism   >   MLXIPL Antibody (C-term)   

MLXIPL Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - MLXIPL Antibody (C-term) AP12562b
    All lanes : Anti-MLXIPL Antibody (C-term) at 1:2000 dilution Lane 1: Neuro-2a whole cell lysate Lane 2: SW620 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 93 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - MLXIPL Antibody (C-term) AP12562b
    All lanes : Anti-MLXIPL Antibody (C-term) at 1:2000 dilution Lane 1: K562 whole cell lysate Lane 2: NCI-H1299 whole cell lysate Lane 3: Neuro-2a whole cell lysate Lane 4: SW620 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 93 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - MLXIPL Antibody (C-term) AP12562b
    MLXIPL Antibody (C-term) (Cat. #AP12562b) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the MLXIPL antibody detected the MLXIPL protein (arrow).
  • IHC-P - MLXIPL Antibody (C-term) AP12562b
    MLXIPL Antibody (C-term) (Cat. #AP12562b)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MLXIPL Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9NP71
Other Accession NP_116571.1, NP_116569.1
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 93073 Da
Antigen Region 624-653 aa
Additional Information
Gene ID 51085
Other Names Carbohydrate-responsive element-binding protein, ChREBP, Class D basic helix-loop-helix protein 14, bHLHd14, MLX interactor, MLX-interacting protein-like, WS basic-helix-loop-helix leucine zipper protein, WS-bHLH, Williams-Beuren syndrome chromosomal region 14 protein, MLXIPL, BHLHD14, MIO, WBSCR14
Target/Specificity This MLXIPL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 624-653 amino acids from the C-terminal region of human MLXIPL.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMLXIPL Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MLXIPL
Synonyms BHLHD14, MIO, WBSCR14
Function Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3' (By similarity).
Cellular Location Nucleus.
Tissue Location Expressed in liver, heart, kidney, cerebellum and intestinal tissues
Research Areas
Citations (0)

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Background

This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23.

References

Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010)
Johansen, C.T., et al. Nat. Genet. 42(8):684-687(2010)
Keebler, M.E., et al. Circ Cardiovasc Genet 3(4):358-364(2010)
Chidambaram, M., et al. Metab. Clin. Exp. (2010) In press :
Reynolds, C.A., et al. Hum. Mol. Genet. 19(10):2068-2078(2010)

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$ 295.00
$ 99.00
Cat# AP12562b
Size:
Quantity:
(40 western blots)
Availability: In Stock
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