|Application ||WB, FC, E|
|Other Accession||P62484, NP_005750.4|
|Calculated MW||55663 Da|
|Antigen Region||1-30 aa|
|Other Names||Abl interactor 2, Abelson interactor 2, Abi-2, Abl-binding protein 3, AblBP3, Arg-binding protein 1, ArgBP1, ABI2, ARGBPIA|
|Target/Specificity||This ABI2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human ABI2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ABI2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA.|
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Provided below are standard protocols that you may find useful for product applications.
ABI2 may act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May be involved in cytoskeletal reorganization. Regulates ABL1/c-Abl-mediated phosphorylation of MENA.
Ryu, J.R., et al. Mol. Cell. Biol. 29(7):1735-1748(2009)
Kano, S., et al. Cancer Res. 68(14):5572-5580(2008)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Li, Y., et al. J. Cell. Sci. 120 (PT 8), 1436-1446 (2007) :
O'Donnell, C.J., et al. BMC Med. Genet. 8 SUPPL 1, S4 (2007) :
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