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>   home   >   Products   >   Primary Antibodies   >   Cardiovascular   >   PNKD Antibody (N-term)   

PNKD Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - PNKD Antibody (N-term) AP12567a
    PNKD Antibody (N-term) (Cat. #AP12567a) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the PNKD antibody detected the PNKD protein (arrow).
  • IHC-P - PNKD Antibody (N-term) AP12567a
    PNKD Antibody (N-term) (Cat. #AP12567a)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PNKD Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q8N490
Other Accession Q69ZP3, A7YY46, NP_001070867.1, NP_056303.3
Reactivity Mouse
Predicted Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 42876 Da
Antigen Region 42-70 aa
Additional Information
Gene ID 25953
Other Names Probable hydrolase PNKD, 3---, Myofibrillogenesis regulator 1, MR-1, Paroxysmal nonkinesiogenic dyskinesia protein, Trans-activated by hepatitis C virus core protein 2, PNKD, KIAA1184, MR1, TAHCCP2
Target/Specificity This PNKD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-70 amino acids from the N-terminal region of human PNKD.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPNKD Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PNKD
Synonyms KIAA1184, MR1, TAHCCP2
Function Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway.
Cellular Location Isoform 1: Membrane; Peripheral membrane protein Isoform 3: Mitochondrion.
Tissue Location Isoform 1 is only expressed in the brain. Isoform 2 is ubiquitously detected with highest expression in skeletal muscle and detected in myocardial myofibrils. Variant Val-7 and Val-9 are detected in the brain only
Research Areas
Citations (0)

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Background

This gene is thought to play a role in the regulation of myofibrillogenesis. Mutations in this gene have been associated with the movement disorder paroxysmal non-kinesigenic dyskinesia. Alternative splicing results in multiple transcript variants.

References

Yang, J., et al. Neuron 66(6):871-883(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Ghezzi, D., et al. Hum. Mol. Genet. 18(6):1058-1064(2009)
Friedman, A., et al. Eur. Neurol. 61(1):39-41(2009)
Ren, K., et al. J. Biol. Chem. 283(51):35598-35605(2008)

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Cat# AP12567a
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(40 western blots)
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