|Application ||WB, IHC-P, E|
|Other Accession||Q69ZP3, A7YY46, NP_001070867.1, NP_056303.3|
|Calculated MW||42876 Da|
|Antigen Region||42-70 aa|
|Other Names||Probable hydrolase PNKD, 3---, Myofibrillogenesis regulator 1, MR-1, Paroxysmal nonkinesiogenic dyskinesia protein, Trans-activated by hepatitis C virus core protein 2, PNKD, KIAA1184, MR1, TAHCCP2|
|Target/Specificity||This PNKD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-70 amino acids from the N-terminal region of human PNKD.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PNKD Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA1184, MR1, TAHCCP2|
|Function||Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway.|
|Cellular Location||Isoform 1: Membrane; Peripheral membrane protein Isoform 3: Mitochondrion.|
|Tissue Location||Isoform 1 is only expressed in the brain. Isoform 2 is ubiquitously detected with highest expression in skeletal muscle and detected in myocardial myofibrils. Variant Val-7 and Val-9 are detected in the brain only|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This gene is thought to play a role in the regulation of myofibrillogenesis. Mutations in this gene have been associated with the movement disorder paroxysmal non-kinesigenic dyskinesia. Alternative splicing results in multiple transcript variants.
Yang, J., et al. Neuron 66(6):871-883(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Ghezzi, D., et al. Hum. Mol. Genet. 18(6):1058-1064(2009)
Friedman, A., et al. Eur. Neurol. 61(1):39-41(2009)
Ren, K., et al. J. Biol. Chem. 283(51):35598-35605(2008)
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