|Application ||WB, IF, E|
|Other Accession||NP_998822.1, NP_002250.1, NP_015567.1, NP_998823.1|
|Calculated MW||26314 Da|
|Antigen Region||1-30 aa|
|Other Names||NKG2-A/NKG2-B type II integral membrane protein, CD159 antigen-like family member A, NK cell receptor A, NKG2-A/B-activating NK receptor, CD159a, KLRC1, NKG2A|
|Target/Specificity||This KLRC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human KLRC1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KLRC1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.|
|Cellular Location||Membrane; Single-pass type II membrane protein|
|Tissue Location||Natural killer cells.|
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Provided below are standard protocols that you may find useful for product applications.
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. [provided by RefSeq].
Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)
Ma, J., et al. J. Med. Virol. 82(9):1501-1507(2010)
Harrison, R.J., et al. Clin. Exp. Immunol. 161(2):306-314(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Beziat, V., et al. PLoS ONE 5 (8), E11966 (2010) :
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