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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   DTNA Antibody (C-term)   

DTNA Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - DTNA Antibody (C-term) AP12573B
    DTNA Antibody (C-term) (Cat. #AP12573b) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the DTNA antibody detected the DTNA protein (arrow).
  • IHC-P - DTNA Antibody (C-term) AP12573B
    DTNA Antibody (C-term) (Cat. #AP12573b)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of DTNA Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • IF - DTNA Antibody (C-term) AP12573B
    Confocal immunofluorescent analysis of DTNA Antibody (C-term) (Cat#AP12573b) with 293 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q9Y4J8
Other Accession NP_116760.2, NP_001383.2
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 83901 Da
Antigen Region 692-721 aa
Additional Information
Gene ID 1837
Other Names Dystrobrevin alpha, DTN-A, Alpha-dystrobrevin, Dystrophin-related protein 3, DTNA, DRP3
Target/Specificity This DTNA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 692-721 amino acids from the C-terminal region of human DTNA.
Dilution WB~~1:1000
IHC-P~~1:10~50
IF~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDTNA Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DTNA
Synonyms DRP3
Function May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.
Cellular Location Cytoplasm. Cell junction, synapse. Cell membrane. Note=In peripheral nerves, colocalizes with MAGEE1 in the Schwann cell membrane.
Tissue Location Highly expressed in brain, skeletal and cardiac muscles, and expressed at lower levels in lung, liver and pancreas. Isoform 2 is not expressed in cardiac muscle. Isoform 7 and isoform 8 are only expressed in muscle
Research Areas
Citations (0)

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Background

The protein encoded by this gene belongs to the dystrobrevin subfamily of the dystrophin family. This protein is a component of the dystrophin-associated protein complex (DPC), which consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha- and beta-dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Mutations in this gene are associated with left ventricular noncompaction with congenital heart defects. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Bohm, S.V., et al. BMC Biol. 7, 85 (2009) :
Nakamori, M., et al. Neurology 70(9):677-685(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Lim, J., et al. Cell 125(4):801-814(2006)

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$ 295.00
$ 99.00
Cat# AP12573B
Size:
Quantity:
(40 western blots)
Availability: In Stock
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