|Application ||WB, IHC-P, E|
|Calculated MW||12829 Da|
|Antigen Region||26-55 aa|
|Other Names||Cocaine- and amphetamine-regulated transcript protein, CART(1-39), CART(42-89), CARTPT, CART|
|Target/Specificity||This CARTPT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-55 amino acids from the N-terminal region of human CARTPT.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CARTPT Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. It promotes neuronal development and survival in vitro.|
|Tissue Location||Hypothalamus. Found in neurons of the ventrolateral part of the arcuate nucleus, in the external zone of the median eminence, and also found in terminals in the periventricular part of the paraventricular nucleus|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a secreted protein which is processed by prohormone/proprotein convertases to produce smaller, biologically active peptides. Expression of the transcript for this gene is regulated by certain drugs such as cocaine, and the encoded protein is thought to be involved in the regulation of appetite and stress. Mutations in this gene are associated with susceptibility to obesity.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Busto, A., et al. Prog. Neuropsychopharmacol. Biol. Psychiatry 34(6):834-836(2010)
Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :
Rigoli, L., et al. Acta Paediatr. 99(5):722-726(2010)
Vasseur, F., et al. J. Hum. Genet. 55(4):227-231(2010)
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