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CBLC Antibody (C-term)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP1258a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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CBLC Antibody (C-term) - Product info | |
| Application | IHC, WB
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| Primary Accession | Q9ULV8 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 52456 Da |
CBLC Antibody (C-term) - Additional info | |
| Gene ID 23624 | |
| Other Names CBLC; CBL3; RNF57; Signal transduction protein CBL-C; RING finger protein 57; SH3-binding protein CBL-3; SH3-binding protein CBL-C | |
| Target/Specificity This CBLC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 172~202 amino acids from the C-terminal region of human Cbl-c. | |
| Dilution IHC~~1:50~100 WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions CBLC Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
CBLC Antibody (C-term) - Protein Information | |
| Name CBLC | |
| Synonyms CBL3, RNF57 | |
| Function Regulator of EGFR mediated signal transduction. | |
| Cellular Location Nucleus (Potential). | |
| Tissue Location Ubiquitous. | |
CBLC Antibody (C-term) - Related products
AP1257a: CBLC Antibody (N-term)
AP1258a: CBLC Antibody (C-term)
DC05882: Human CBLC cDNA Clone
CBLC Antibody (C-term) - Application data
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Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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CBLC Antibody (R439) (Cat. #AP1258a) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the CBLC antibody detected the CBLC protein (arrow).
CBLC Antibody (C-term) - Research Areas
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BACKGROUND
Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
REFERENCES
Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002). Keane, M.M., et al., Oncogene 18(22):3365-3375 (1999). Kim, M., et al., Gene 239(1):145-154 (1999).
