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SENP8 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SENP8 Antibody (N-term) AP1259a
    Western blot analysis of SENP8 polyclonal antibody (Cat. #AP1259a) in mouse spleen lysate. SENP8 (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
  • WB - SENP8 Antibody (N-term) AP1259a
    Western blot analysis of SENP8 (arrow) using rabbit polyclonal SENP8 Antibody (S19) (Cat. #AP1259a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the SENP8 gene.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96LD8
Other Accession Q9D2Z4
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 24107 Da
Antigen Region 4-35 aa
Additional Information
Gene ID 123228
Other Names Sentrin-specific protease 8, Deneddylase-1, NEDD8-specific protease 1, Protease, cysteine 2, Sentrin/SUMO-specific protease SENP8, SENP8, DEN1, NEDP1, PRSC2
Target/Specificity This SENP8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-35 amino acids from the N-terminal region of human SENP8.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSENP8 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SENP8
Synonyms DEN1, NEDP1, PRSC2
Function Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53.
Tissue Location Broadly expressed, with highest levels in kidney and pancreas.
Research Areas
Citations (0)

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NEDD8 is a ubiquitin-like protein that becomes conjugated to the cullin subunit of several ubiquitin ligases. This conjugation, called neddylation, is required for optimal ubiquitin ligase activity. SENP8 is a protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53.


Wu, K., et al., J. Biol. Chem. 278(31):28882-28891 (2003).
Gan-Erdene, T., et al., J. Biol. Chem. 278(31):28892-28900 (2003).
Mendoza, H.M., et al., J. Biol. Chem. 278(28):25637-25643 (2003).

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$ 295.00
$ 99.00
Cat# AP1259a
(40 western blots)
Availability: In Stock
Bulk Size
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