|Application ||WB, IHC-P, FC, E|
|Other Accession||P09034, P16460, Q5ZJ23, P14568, NP_446464.1, NP_000041.2|
|Predicted||Bovine, Chicken, Mouse, Rat|
|Calculated MW||46530 Da|
|Antigen Region||281-310 aa|
|Other Names||Argininosuccinate synthase, Citrulline--aspartate ligase, ASS1, ASS|
|Target/Specificity||This ASS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 281-310 amino acids from the C-terminal region of human ASS1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ASS1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues.|
|Cellular Location||Cytoplasm, cytosol|
|Tissue Location||Expressed in adult liver.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene catalyzes the penultimate step of the arginine biosynthetic pathway. There are approximately 10 to 14 copies of this gene including the pseudogenes scattered across the human genome, among which the one located on chromosome 9 appears to be the only functional gene for argininosuccinate synthetase. Mutations in the chromosome 9 copy of ASS cause citrullinemia. Two transcript variants encoding the same protein have been found for this gene.
Hozyasz, K.K., et al. Arch. Oral Biol. 55(11):861-866(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Kobayashi, E., et al. Mol. Cancer Ther. 9(3):535-544(2010)
Tsai, W.B., et al. Mol. Cancer Ther. 8(12):3223-3233(2009)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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