|Application ||IHC-P, WB, E|
|Calculated MW||65444 Da|
|Antigen Region||527-556 aa|
|Other Names||NAD-dependent malic enzyme, mitochondrial, NAD-ME, Malic enzyme 2, ME2|
|Target/Specificity||This ME2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 527-556 amino acids from the C-terminal region of human ME2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ME2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Mitochondrion matrix.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene. [provided by RefSeq].
MacDonald, M.J., et al. Arch. Biochem. Biophys. 488(2):100-104(2009)
French, D., et al. Blood 113(19):4512-4520(2009)
Escamilla, M. Pharmacogenomics 8(7):691-695(2007)
Chou, W.Y., et al. Biochem. Biophys. Res. Commun. 357(1):133-138(2007)
Lenzen, K.P., et al. Epilepsia 46(10):1637-1641(2005)
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