|Application ||IHC-P, WB, E|
|Other Accession||Q9WUK2, NP_114381.1|
|Calculated MW||27385 Da|
|Antigen Region||127-156 aa|
|Other Names||Eukaryotic translation initiation factor 4H, eIF-4H, Williams-Beuren syndrome chromosomal region 1 protein, EIF4H, KIAA0038, WBSCR1, WSCR1|
|Target/Specificity||This EIF4H antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 127-156 amino acids from the Central region of human EIF4H.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||EIF4H Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA0038, WBSCR1, WSCR1|
|Function||Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.|
|Cellular Location||Cytoplasm, perinuclear region.|
|Tissue Location||The short isoform is the predominant isoform and is expressed alone in liver and skeletal muscle. Both isoforms are expressed in fibroblast, spleen, testis and bone marrow Levels are high in lung and pancreas and low in heart, frontal cortex and kidney.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes one of the translation initiation factors, which functions to stimulate the initiation of protein synthesis at the level of mRNA utilization. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants.
Feng, T., et al. Hum. Genet. 128(3):269-280(2010)
Zhu, X., et al. Genet. Epidemiol. 34(2):171-187(2010)
Mokas, S., et al. Mol. Biol. Cell 20(11):2673-2683(2009)
Marintchev, A., et al. Cell 136(3):447-460(2009)
Rozovsky, N., et al. RNA 14(10):2136-2148(2008)
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