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UGDH Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - UGDH Antibody (C-term) AP12613b
    UGDH Antibody (C-term) (Cat. #AP12613b) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the UGDH antibody detected the UGDH protein (arrow).
    detail
  • IHC-P - UGDH Antibody (C-term) AP12613b
    UGDH Antibody (C-term) (Cat. #AP12613b)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of UGDH Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, WB, E
Primary Accession O60701
Other Accession O70199, O70475, NP_003350.1, NP_001171629.1
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 55024 Da
Antigen Region 465-494 aa
Additional Information
Gene ID 7358
Other Names UDP-glucose 6-dehydrogenase, UDP-Glc dehydrogenase, UDP-GlcDH, UDPGDH, UGDH
Target/Specificity This UGDH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 465-494 amino acids from the C-terminal region of human UGDH.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsUGDH Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name UGDH
Function Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (PubMed:21961565, PubMed:21502315, PubMed:23106432, PubMed:22123821, PubMed:25478983, PubMed:27966912, PubMed:30420606, PubMed:30457329). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity). Required for proper brain and neuronal development (PubMed:32001716).
Tissue Location Detected in heart, placenta, liver, pancreas, spleen, thymus, prostate, ovary, small intestine and colon (PubMed:9737970). Widely expressed (PubMed:9737970)
Research Areas
Citations (0)
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Background

The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.

References

Wang, T.P., et al. Exp. Cell Res. 316(17):2893-2902(2010)
Hodgkinson, C.A., et al. Proc. Natl. Acad. Sci. U.S.A. 107(19):8695-8700(2010)
Huang, D., et al. Int. J. Cancer 126(2):315-327(2010)
Lee, H.S., et al. Arch. Biochem. Biophys. 486(1):35-43(2009)
Pan, Y.R., et al. Cell. Microbiol. 10(12):2447-2460(2008)

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$ 182.50
$ 70.00
Cat# AP12613b
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