|Application ||WB, IHC-P, E|
|Other Accession||O70199, O70475, NP_003350.1, NP_001171629.1|
|Calculated MW||55024 Da|
|Antigen Region||465-494 aa|
|Other Names||UDP-glucose 6-dehydrogenase, UDP-Glc dehydrogenase, UDP-GlcDH, UDPGDH, UGDH|
|Target/Specificity||This UGDH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 465-494 amino acids from the C-terminal region of human UGDH.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||UGDH Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.
Wang, T.P., et al. Exp. Cell Res. 316(17):2893-2902(2010)
Hodgkinson, C.A., et al. Proc. Natl. Acad. Sci. U.S.A. 107(19):8695-8700(2010)
Huang, D., et al. Int. J. Cancer 126(2):315-327(2010)
Lee, H.S., et al. Arch. Biochem. Biophys. 486(1):35-43(2009)
Pan, Y.R., et al. Cell. Microbiol. 10(12):2447-2460(2008)
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