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KERA Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, IHC-P-Leica, E |
|---|---|
| Primary Accession | O60938 |
| Other Accession | NP_008966.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 40509 Da |
| Antigen Region | 228-257 aa |
| Gene ID | 11081 |
|---|---|
| Other Names | Keratocan, KTN, Keratan sulfate proteoglycan keratocan, KERA, SLRR2B |
| Target/Specificity | This KERA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 228-257 amino acids from the C-terminal region of human KERA. |
| Dilution | WB~~1:1000 IHC-P-Leica~~1:500 FC~~1:25 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | KERA Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KERA |
|---|---|
| Synonyms | SLRR2B |
| Function | May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix. |
| Cellular Location | Secreted, extracellular space, extracellular matrix |
| Tissue Location | Cornea (at protein level) (PubMed:10802664, PubMed:11683372). Increased expression in the stroma of keratoconus corneas (PubMed:11683372). Also detected in trachea, and in low levels, in intestine, skeletal muscle, ovary, lung and putamen (PubMed:10802664). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a keratan sulfate proteoglycan that is involved in corneal transparency. Defects in this gene are a cause of autosomal recessive cornea plana 2 (CNA2).
References
Aldave, A.J., et al. Invest. Ophthalmol. Vis. Sci. 51(8):4006-4012(2010)
Dimasi, D.P., et al. Mol. Vis. 16, 562-569 (2010) :
Wheeler, H.E., et al. PLoS Genet. 5 (10), E1000685 (2009) :
Melrose, J., et al. Arthritis Res. Ther. 10 (4), R79 (2008) :
Liskova, P., et al. Mol. Vis. 13, 1339-1347 (2007) :
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