|Application ||WB, E|
|Calculated MW||40509 Da|
|Antigen Region||228-257 aa|
|Other Names||Keratocan, KTN, Keratan sulfate proteoglycan keratocan, KERA, SLRR2B|
|Target/Specificity||This KERA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 228-257 amino acids from the C-terminal region of human KERA.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KERA Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Cornea. Increased expression in the stroma of keratoconus corneas. Also detected in trachea, and in low levels, in intestine, skeletal muscle, ovary, lung and putamen|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a keratan sulfate proteoglycan that is involved in corneal transparency. Defects in this gene are a cause of autosomal recessive cornea plana 2 (CNA2).
Aldave, A.J., et al. Invest. Ophthalmol. Vis. Sci. 51(8):4006-4012(2010)
Dimasi, D.P., et al. Mol. Vis. 16, 562-569 (2010) :
Wheeler, H.E., et al. PLoS Genet. 5 (10), E1000685 (2009) :
Melrose, J., et al. Arthritis Res. Ther. 10 (4), R79 (2008) :
Liskova, P., et al. Mol. Vis. 13, 1339-1347 (2007) :
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