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TMEM43 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - TMEM43 Antibody (Center) AP12618c
    TMEM43 Antibody (Center) (Cat. #AP12618c) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the TMEM43 antibody detected the TMEM43 protein (arrow).
  • IHC-P - TMEM43 Antibody (Center) AP12618c
    TMEM43 Antibody (Center) (Cat. #AP12618c)immunohistochemistry analysis in formalin fixed and paraffin embedded human esophageal carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TMEM43 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9BTV4
Other Accession Q5XIP9, Q9DBS1, NP_077310.1
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 44876 Da
Antigen Region 195-223 aa
Additional Information
Gene ID 79188
Other Names Transmembrane protein 43, Protein LUMA, TMEM43
Target/Specificity This TMEM43 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 195-223 amino acids from the Central region of human TMEM43.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTMEM43 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TMEM43
Function May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (By similarity).
Cellular Location Endoplasmic reticulum. Nucleus inner membrane; Multi-pass membrane protein. Note=Retained in the inner nuclear membrane through interaction with EMD and A- and B- lamins. The N- and C-termini are oriented towards the nucleoplasm The majority of the hydrophilic domain resides in the endoplasmic reticulum lumen (By similarity).
Tissue Location Highest expression in placenta. Also found at lower levels in heart, ovary, spleen, small intestine, thymus, prostate and testis.
Research Areas
Citations (0)

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This gene belongs to the TMEM43 family. Defects in this gene are the cause of familial arrhythmogenic right ventricular dysplasia type 5 (ARVD5), also known as arrhythmogenic right ventricular cardiomyopathy type 5 (ARVC5). Arrhythmogenic right ventricular dysplasia is an inherited disorder, often involving both ventricles, and is characterized by ventricular tachycardia, heart failure, sudden cardiac death, and fibrofatty replacement of cardiomyocytes. This gene contains a response element for PPAR gamma (an adipogenic transcription factor), which may explain the fibrofatty replacement of the myocardium, a characteristic pathological finding in ARVC.


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Barahona-Dussault, C., et al. Clin. Genet. 77(1):37-48(2010)
Hodgkinson, K., et al. Genet. Med. 11(12):859-865(2009)
Merner, N.D., et al. Am. J. Hum. Genet. 82(4):809-821(2008)
Bengtsson, L., et al. J. Cell. Sci. 121 (PT 4), 536-548 (2008) :

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$ 295.00
$ 99.00
Cat# AP12618c
(40 western blots)
Availability: In Stock
Bulk Size
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