|Application ||WB, E|
|Other Accession||NP_945322.1, NP_056332.2|
|Calculated MW||59678 Da|
|Antigen Region||317-346 aa|
|Other Names||Histone H4 transcription factor, Histone nuclear factor P, HiNF-P, MBD2-interacting zinc finger protein, Methyl-CpG-binding protein 2-interacting zinc finger protein, HINFP, MIZF, ZNF743|
|Target/Specificity||This HINFP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 317-346 amino acids from the Central region of human HINFP.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HINFP Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter.|
|Cellular Location||Nucleus. Note=Associated with discrete nuclear foci|
|Tissue Location||Ubiquitous. Highly expressed in brain, heart, skeletal muscle, spleen, kidney, small intestine, placenta and liver.|
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Provided below are standard protocols that you may find useful for product applications.
MIZF interacts with methyl-CpG-binding protein-2 (MBD2; MIM 603547), a component of the MeCP1 histone deacetylase (HDAC) complex, and plays a role in DNA methylation and transcription repression.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Mitra, P., et al. J. Cell. Physiol. 219(2):438-448(2009)
Medina, R., et al. Biochemistry 47(44):11415-11423(2008)
Medina, R., et al. Cancer Res. 67(21):10334-10342(2007)
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