|Application ||WB, E|
|Other Accession||NP_945322.1, NP_056332.2|
|Calculated MW||59678 Da|
|Antigen Region||317-346 aa|
|Other Names||Histone H4 transcription factor, Histone nuclear factor P, HiNF-P, MBD2-interacting zinc finger protein, Methyl-CpG-binding protein 2-interacting zinc finger protein, HINFP, MIZF, ZNF743|
|Target/Specificity||This HINFP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 317-346 amino acids from the Central region of human HINFP.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HINFP Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter.|
|Cellular Location||Nucleus. Note=Associated with discrete nuclear foci|
|Tissue Location||Ubiquitous. Highly expressed in brain, heart, skeletal muscle, spleen, kidney, small intestine, placenta and liver.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
MIZF interacts with methyl-CpG-binding protein-2 (MBD2; MIM 603547), a component of the MeCP1 histone deacetylase (HDAC) complex, and plays a role in DNA methylation and transcription repression.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Mitra, P., et al. J. Cell. Physiol. 219(2):438-448(2009)
Medina, R., et al. Biochemistry 47(44):11415-11423(2008)
Medina, R., et al. Cancer Res. 67(21):10334-10342(2007)
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