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ABCD2 Antibody (C-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP12623b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP12623b-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
ABCD2 Antibody (C-term) - Product info | |
| Application | WB, IHC, FC
|
| Primary Accession | Q9UBJ2 |
| Other Accession | NP_005155.1 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 83233 Da |
ABCD2 Antibody (C-term) - Additional info | |
| Gene ID 225 | |
| Other Names ABCD2; ALD1; ALDL1; ALDR; ALDRP; ATP-binding cassette sub-family D member 2; Adrenoleukodystrophy-like 1; Adrenoleukodystrophy-related protein | |
| Target/Specificity This ABCD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 552-582 amino acids from the C-terminal region of human ABCD2. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:10~50 FC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ABCD2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
ABCD2 Antibody (C-term) - Protein Information | |
| Name ABCD2 | |
| Synonyms ALD1, ALDL1, ALDR, ALDRP | |
| Function Probable transporter. | |
| Cellular Location Peroxisome membrane; Multi-pass membrane protein | |
| Tissue Location Predominantly expressed in brain and heart. | |
ABCD2 Antibody (C-term) - Related products
AP12623b: ABCD2 Antibody (C-term)
ABCD2 Antibody (C-term) - Application data
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ABCD2 Antibody (C-term) (Cat. #AP12623b) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the ABCD2 antibody detected the ABCD2 protein (arrow).
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ABCD2 Antibody (C-term) (Cat. #AP12623b)immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ABCD2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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ABCD2 Antibody (C-term) (Cat. #AP12623b) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.
ABCD2 Antibody (C-term) - Research Areas
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BACKGROUND
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters. Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, accounting for the extreme variation among adrenoleukodystrophy phenotypes. This gene is also a candidate for a complement group of Zellweger syndrome, a genetically heterogeneous disorder of peroxisomal biogenesis.
REFERENCES
Matsukawa, T., et al. Neurogenetics (2010) In press : Saito, A., et al. J. Hum. Genet. 54(6):317-323(2009) Maier, E.M., et al. Biochem. Biophys. Res. Commun. 377(1):176-180(2008) Lu, Y., et al. J. Lipid Res. 49(12):2582-2589(2008) Petroni, A., et al. J. Inherit. Metab. Dis. 30 (5), 828 (2007) :
