|Application ||WB, IHC-P, E|
|Other Accession||Q9QZZ6, NP_001928.2|
|Calculated MW||24005 Da|
|Antigen Region||45-72 aa|
|Other Names||Dermatopontin, Tyrosine-rich acidic matrix protein, TRAMP, DPT|
|Target/Specificity||This DPT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 45-72 amino acids from the N-terminal region of human DPT.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DPT Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity).|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Expressed in fibroblasts, heart, skeletal muscle, brain and pancreas. Expressed at an intermediate level in lung and kidney, and at a low level in liver and placenta Expressed at a lower level in fibroblasts from hypertrophic scar lesional skin and in fibroblasts from patients with systemic sclerosis than in normal skin fibroblasts|
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Provided below are standard protocols that you may find useful for product applications.
Dermatopontin is an extracellular matrix protein with possible functions in cell-matrix interactions and matrix assembly. The protein is found in various tissues and many of its tyrosine residues are sulphated. Dermatopontin is postulated to modify the behavior of TGF-beta through interaction with decorin. [provided by RefSeq].
Ehret, G.B., et al. Eur. J. Hum. Genet. 17(12):1650-1657(2009)
Li, X., et al. Biochemistry Mosc. 74(9):979-985(2009)
Cheung, C.L., et al. Hum. Mol. Genet. 18(4):679-687(2009)
Pochampally, R.R., et al. J. Bone Miner. Res. 22(9):1338-1349(2007)
Lunetta, K.L., et al. BMC Med. Genet. 8 SUPPL 1, S13 (2007) :
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