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CA1 Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | P00915 |
| Other Accession | NP_001122301.1, NP_001122302.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 28870 Da |
| Antigen Region | 60-90 aa |
| Gene ID | 759 |
|---|---|
| Other Names | Carbonic anhydrase 1, Carbonate dehydratase I, Carbonic anhydrase B, CAB, Carbonic anhydrase I, CA-I, CA1 |
| Target/Specificity | This CA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 60-90 amino acids from the N-terminal region of human CA1. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CA1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CA1 |
|---|---|
| Function | Catalyzes the reversible hydration of carbon dioxide (PubMed:10550681, PubMed:18618712, PubMed:16807956, PubMed:16686544, PubMed:17127057, PubMed:19186056, PubMed:19206230, PubMed:16506782, PubMed:17314045, PubMed:17407288). Can hydrate cyanamide to urea (PubMed:10550681). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:B0BNN3}. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA1 is closely linked to CA2 and CA3 genes on chromosome 8, and it encodes a cytosolic protein which is found at the highest level in erythrocytes. Variants of this gene have been described in some populations. Multiple alternatively spliced variants, encoding the same protein, have been identified. Transcript variants of CA1 utilizing alternative polyA_sites have been described in literature.
References
Abhary, S., et al. Mol. Vis. 15, 1179-1184 (2009) :
Gambhir, K.K., et al. Biochem. Genet. 45 (5-6), 431-439 (2007) :
Temperini, C., et al. Bioorg. Med. Chem. Lett. 17(8):2210-2215(2007)
Temperini, C., et al. Bioorg. Med. Chem. Lett. 16(19):5152-5156(2006)
Dawson, S.J., et al. J. Infect. 24(3):317-320(1992)
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