|Application ||WB, IHC-P, FC, E|
|Other Accession||NP_001122301.1, NP_001122302.1|
|Calculated MW||28870 Da|
|Antigen Region||60-90 aa|
|Other Names||Carbonic anhydrase 1, Carbonate dehydratase I, Carbonic anhydrase B, CAB, Carbonic anhydrase I, CA-I, CA1|
|Target/Specificity||This CA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 60-90 amino acids from the N-terminal region of human CA1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CA1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea.|
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Provided below are standard protocols that you may find useful for product applications.
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA1 is closely linked to CA2 and CA3 genes on chromosome 8, and it encodes a cytosolic protein which is found at the highest level in erythrocytes. Variants of this gene have been described in some populations. Multiple alternatively spliced variants, encoding the same protein, have been identified. Transcript variants of CA1 utilizing alternative polyA_sites have been described in literature.
Abhary, S., et al. Mol. Vis. 15, 1179-1184 (2009) :
Gambhir, K.K., et al. Biochem. Genet. 45 (5-6), 431-439 (2007) :
Temperini, C., et al. Bioorg. Med. Chem. Lett. 17(8):2210-2215(2007)
Temperini, C., et al. Bioorg. Med. Chem. Lett. 16(19):5152-5156(2006)
Dawson, S.J., et al. J. Infect. 24(3):317-320(1992)
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