|Application ||WB, IHC-P, E|
|Other Accession||NP_671736.2, NP_963847.1|
|Calculated MW||36379 Da|
|Antigen Region||218-247 aa|
|Other Names||Fibrinogen-like protein 1, HP-041, Hepassocin, Hepatocyte-derived fibrinogen-related protein 1, HFREP-1, Liver fibrinogen-related protein 1, LFIRE-1, FGL1, HFREP1|
|Target/Specificity||This FGL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-247 amino acids from the C-terminal region of human FGL1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FGL1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Has hepatocyte mitogenic activity.|
|Tissue Location||Liver specific.|
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Provided below are standard protocols that you may find useful for product applications.
Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene.
Bailey, S.D., et al. Diabetes Care (2010) In press :
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Segat, L., et al. J. Gastroenterol. Hepatol. 24(12):1840-1846(2009)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Yu, H.T., et al. J. Biol. Chem. 284(20):13335-13347(2009)
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