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CEBPD Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P49716 |
| Other Accession | Q03484, Q00322, O02756, NP_005186.2, Q9N0J3 |
| Reactivity | Human |
| Predicted | Bovine, Mouse, Rat, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 28467 Da |
| Antigen Region | 169-197 aa |
| Gene ID | 1052 |
|---|---|
| Other Names | CCAAT/enhancer-binding protein delta, C/EBP delta, Nuclear factor NF-IL6-beta, NF-IL6-beta, CEBPD |
| Target/Specificity | This CEBPD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 169-197 amino acids from the C-terminal region of human CEBPD. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CEBPD Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CEBPD |
|---|---|
| Function | Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:16397300). Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:16397300). Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (PubMed:1741402). |
| Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages. The cytogenetic location of this locus has been reported as both 8p11 and 8q11.
References
Zannetti, C., et al. J. Biol. Chem. 285(45):34773-34780(2010)
Wang, J., et al. Proc. Natl. Acad. Sci. U.S.A. 107(37):16131-16136(2010)
Hour, T.C., et al. Biochem. Pharmacol. 80(3):325-334(2010)
Bennett, C.E., et al. Diab Vasc Dis Res 7(3):195-203(2010)
Payne, V.A., et al. Biochem. J. 425(1):215-223(2010)
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