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KRTAP1-3 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, WB, E |
|---|---|
| Primary Accession | Q8IUG1 |
| Other Accession | Q9BYS1, Q07627, NP_112228.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 17141 Da |
| Antigen Region | 1-3 aa |
| Gene ID | 81850 |
|---|---|
| Other Names | Keratin-associated protein 1-3, Keratin-associated protein 18, Keratin-associated protein 19, KRTAP1-3 |
| Target/Specificity | This KRTAP1-3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 88-117 amino acids from the Central region of human KRTAP1-3. |
| Dilution | WB~~1:1000 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | KRTAP1-3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KRTAP1-3 |
|---|---|
| Function | In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. |
| Tissue Location | Expressed in the middle/upper portions of the hair cortex, in the region termed the keratogenous zone |
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Provided below are standard protocols that you may find useful for product applications.
Background
This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the high sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. [provided by RefSeq].
References
Shimomura, Y., et al. J. Biol. Chem. 277(47):45493-45501(2002)
Rogers, M.A., et al. J. Biol. Chem. 276(22):19440-19451(2001)
Zhumabaeva, B.D., et al. Mol. Biol. (Mosk.) 26(4):813-820(1992)
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