|Application ||WB, E|
|Other Accession||O35431, P98084, NP_005494.2, NP_001123886.1|
|Calculated MW||82512 Da|
|Antigen Region||307-336 aa|
|Other Names||Amyloid beta A4 precursor protein-binding family A member 2, Adapter protein X11beta, Neuron-specific X11L protein, Neuronal Munc18-1-interacting protein 2, Mint-2, APBA2, MINT2, X11L|
|Target/Specificity||This APBA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 307-336 amino acids from the Central region of human APBA2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||APBA2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Swistowski, A., et al. J. Neurosci. 29(50):15703-15712(2009)
Mitchell, J.C., et al. Hum. Mol. Genet. 18(23):4492-4500(2009)
Babatz, T.D., et al. Autism Res 2(6):359-364(2009)
Chang, S.J., et al. BMC Genomics 10, 613 (2009) :
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