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APBA2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q99767 |
| Other Accession | O35431, P98084, NP_005494.2, NP_001123886.1 |
| Reactivity | Mouse |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 82512 Da |
| Antigen Region | 307-336 aa |
| Gene ID | 321 |
|---|---|
| Other Names | Amyloid beta A4 precursor protein-binding family A member 2, Adapter protein X11beta, Neuron-specific X11L protein, Neuronal Munc18-1-interacting protein 2, Mint-2, APBA2, MINT2, X11L |
| Target/Specificity | This APBA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 307-336 amino acids from the Central region of human APBA2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | APBA2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | APBA2 |
|---|---|
| Synonyms | MINT2, X11L |
| Function | Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. |
| Tissue Location | Brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Swistowski, A., et al. J. Neurosci. 29(50):15703-15712(2009)
Mitchell, J.C., et al. Hum. Mol. Genet. 18(23):4492-4500(2009)
Babatz, T.D., et al. Autism Res 2(6):359-364(2009)
Chang, S.J., et al. BMC Genomics 10, 613 (2009) :
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