- CITATIONS: 1
|Application ||WB, E|
|Calculated MW||37130 Da|
|Antigen Region||213-241 aa|
|Other Names||Tenomodulin, TeM, hTeM, Chondromodulin-1-like protein, ChM1L, hChM1L, Chondromodulin-I-like protein, Myodulin, Tendin, TNMD, CHM1L|
|Target/Specificity||This TNMD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 213-241 amino acids from the Central region of human TNMD.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TNMD Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be an angiogenesis inhibitor.|
|Cellular Location||Isoform 1: Membrane; Single- pass type II membrane protein. Nucleus envelope Isoform 3: Cytoplasm.|
|Tissue Location||Highly expressed in hypovascular connective tissues such as tendons. Has also strong expression in adipose tissue.|
Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that is related to chondromodulin-I, which is a cartilage-specific glycoprotein that functions to stimulate chondrocyte growth and to inhibit tube formation of endothelial cells. This protein is also an angiogenesis inhibitor. Genetic variation in this gene is associated with a risk for type 2 diabetes, central obesity and serum levels of systemic immune mediators in a body size-dependent manner. This gene is also a candidate gene for age-related macular degeneration, though a direct link has yet to be demonstrated.
Saiki, A., et al. J. Clin. Endocrinol. Metab. 94(10):3987-3994(2009)
Tolppanen, A.M., et al. Neurobiol. Aging (2009) In press :
Tolppanen, A.M., et al. Mol. Vis. 15, 762-770 (2009) :
Tolppanen, A.M., et al. Int J Obes (Lond) 32(12):1868-1872(2008)
Kimura, N., et al. Circulation 118(17):1737-1747(2008)
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